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I always marinade venison for a while before smoke. Once I put the meat in the smoke, I keep the marinade close by. About once an hour I take the meat and soak it back in the marinade for a minute and back in the smoke. This helps me keep the venison juicy and also adds a great sticky glaze over the meat that also holds in the juices. Also depending on what I am going to do with the meat afterwards, I may even put the meat in the marinade and all of it back in the smoker or just on the grill. Let the cooked meat simmer in there for a few minutes and its awesome. If the meat is to be sliced up for serving, I will slice it and then simmer it in the marinade. Options are endless.
thanks matt for your input. im planning on useing a hq roast and smoking over applewood. but first i gotta try to smoke this beef heart. wish me luck eh!