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I did that the first couple times (smoked in the garage), but I ran a fan to blow the smoke out the door. The Mrs. didn't want the garage all smokey (I love the smell). I moved to the front porch, because I wouldn't want to blow a fan at the smoker in the winter. My front porch has a roof, and 3 sides open, so no smoke stays around.
No problem smoking in the garage other than it was very cold and windy. Smoked during the storm last Sunday. My MES only made it up to 208 degrees at it's hottest. The ribs took 7 1/2 hours and were not "fall off the bone".