22 lb Turkey, brined, 275 degrees max on smoker

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I'd figure 30 minutes per pound. That should be fairly close. That's a big bird. If it was me I'd spatchcock the bird, or cut it in half. Either of those methods would cut the cook time down considerably.
 
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Dirtsailor is probably pretty close with the 30 mins a pound. @275
I'm not sure what your cooking it on.
But with brining it should be pretty moist.

I done a 15lb turkey @300 and it took me about 3 hours. Lately I have been cooking a lot of turkey breasts. A little more expensive but a lot easier to cook.
The key is finding them on sale.

Good Luck
 
That's an awful big turkey. Going to be hard to get it past 140 in 4 hours, unless you spatchcock it.

Good luck.

Al
 
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